Celebrating Our 15th Anniversary Worldwide! Made in USA.

Favored by Wine & Beer Enthusiasts Worldwide

120-tablet bottle. Serving size: 2 tablets. 

Can be taken before, during, or after consumption of alcohol.

Over 132,000,000 tablets sold!

If you'd like to purchase RU-21 locally in South Korea, UK, Australia & New Zealand, and China, please click on the icon below to connect to our local distributor

Tribune (Oakland, CA), , Medserv Medical News, Mountain News (Denver, CO), Product Alert (Naples, NY), Home News Tribune (East Brunswick, NJ), California Beverage News, Tribune (San Marino, CA), Internal Medicine News, News (Birmingham, AL), Tribune, Democrat (Johnstown, PA), Plain Dealer (Cleveland, OH), Drug Topics (Montvale, NJ), The Daily Star (Lebanon), The News-Enterprise (Hardin County, KY), Sun-Times (Chicago, IL), Advocate (Stamford, CT), The Age (Melbourne, AU)

Steamboat Pilot & Today (Steamboat Springs, CO, Philadelphia Weekly, , Daily Princtonian (Princeton, NJ), Cornell Daily Sun (Ithaca, NY), Tufts Daily (Medford, MA), Daily Egyptian (Carbondale, IL), Daily Illini (University of Illinois), Daily Aztec (San Diego, CA), Fashion (Toronto, ON), Northern Star (DeKalb, IL), Daily News (Muncie, IN), Collegiate Times (Blacksburg, VA), Daily Forty Niner (Long Beach, CA), Ka Leo O Hawaii (Honolulu, HI), Wesleyan Argus (Middleton, CT), Maneater (Columbia, MO), Daily Egyptian (Carbondale, IL), Minnesota Daily, The St. Petersburg Times,  Independent (Burbank, IL), Daily Kent Star (Kent, OH), California Aggie (Davis, CA). 

"Raising thumbs up!"

NY Post


Men's Health

"Trust us, it really, really works!"


"My Head Was Clear"

Budget Living Magazine

Frequently Asked Questions

1. How will I benefit from RU-21?

Take RU-21 piroir, during, or/and after consuming alcoholic beverages, and wake up clear and energetic the morning after.

2. Does RU-21 contain any pharmaceutical ingredients?

No. RU-21 is a dietary supplement, and thus doesn't contain any pharmaceutical ingredients.

3. Will RU-21 work for me?

While individual results may vary, RU-21 is backed by an unconditional money-back guarante. This means that if, for any reason, you are not satisfied with RU-21, we will refund 100% of the purchase price, no questions asked. 

4. Does RU-21 prevent inebriation?

Absolutely not. RU-21 doesn't affect the level of inebriation.

The RU-21 Story: A hot pill from the Cold War

In 2002 several TV news outlets reported that a pill previously used by KGB agents to prevent hangovers was being launched on US market. The Cold War aspect of the story attracted an  initial media interest. Many journalists set out to test the product’s effectiveness and came back with overwhelmingly positive reports. Before long, RU-21 was named “Hot Product of the Year” by the Rolling Stone Magazine, and was featured  in TV programs and glossy magazines. Thanks to the powerful combination of media exposure and word-of-mouth, RU-21 was established as one of the world’s most popular supplements among consumers of alcohol within a year. Today, 15 years later, RU-21 is still going strong, with a dedicated following around the world!

Celebrating Our 15th Anniversary Worldwide!

It's hard to believe that it's been 15 years since we first launched RU-21. The first iPhone was still about 2 years away. Neither Facebook or Instagram existed yet. Life has changed quite a bit since then. But certain things remain the same. We still want life to be eventful and rewarding. It's still important sometimes to slow down, savor the moment, hit a reset button with a glass of wine... And when you do, have your RU-21 handy, because tomorrow is a new day. From the bottom of our hearts, thank you for supporting us throughout these years!

Our international teams celebrate with us!